Keynote lecture 'Using genetic approaches to study antiviral immunity'

Sara Cherry, PhD.

Sara Cherry is a Professor of Microbiology, Scientific Director of the High-throughput Screening Core and Sara Cherry - Keynote speakers NVVI Annual Meeting 2017Director of Chemogenomic Discovery at the University of Pennsylvania.

She applies high-throughput screening technology to discover mechanisms by which diverse viral pathogens hijack cellular machinery while evading defenses. By comparing and contrasting host factor dependencies across diverse viruses and disparate hosts, her lab has revealed novel biological insights into immune defense, and illuminated the unusual biology of viral organisms largely focusing on vector-borne viruses. Her lab continues to explore the interface of viruses, including globally important emerging pathogens, with hosts to discover new therapeutic targets.

Selected publications:

  • Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. 
    Rausch K, Hackett BA, Weinbren NL, Reeder SM, Sadovsky Y, Hunter CA, Schultz DC, Coyne CB, Cherry S.
    Cell Rep. 2017 Jan 17;18(3):804-815.
  • Attacked from All Sides: RNA Decay in Antiviral Defense.
    Molleston JM, Cherry S.
    Viruses. 2017 Jan 4;9(1). pii: E2. doi: 10.3390/v9010002. Review.
  • A CRISPR screen defines a signal peptide processing pathway required by flaviviruses.
    Zhang R, Miner JJ, Gorman MJ, Rausch K, Ramage H, White JP, Zuiani A, Zhang P, Fernandez E, Zhang Q, Dowd KA, Pierson TC, Cherry S, Diamond MS.
    Nature. 2016 Jul 7;535(7610):164-8.
  • Virus-Host Interactions: From Unbiased Genetic Screens to Function.
    Ramage H, Cherry S.
    Annu Rev Virol. 2015 Nov;2(1):497-524.
  • RNASEK is required for internalization of diverse acid-dependent viruses.
    Hackett BA, Yasunaga A, Panda D, Tartell MA, Hopkins KC, Hensley SE, Cherry S.
    Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7797-802.
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