Closing Lecture: The immunological synapse and the syntax of immune cell communications
Michael Dustin, Oxford, United Kingdom
Immune cells use many molecules to communicate with each other in host-defense and errors in this communication can lead to pathology. A subset these molecules are membrane anchored and require close cell-cell contact to deliver messages, including the T cell antigen receptor and its ligand the MHC protein-peptide complex, along with many molecules that assist this recognition process. These surface molecules can be thought of as words in a language and the immunological synapse in which they interact provides a structure, or syntax, for interpretation of these words. I will focus my talk on how the two major adhesion molecules of T cells- the integrin family member LFA-1 and the immunoglobulin superfamily member CD2 alter the way in which the antigen receptor, co-stimulatory and checkpoint receptors interactions are interpreted based on concepts of phase separation and protein-protein interaction.