Mechanistic studies on long peptide-based vaccines for the use in cancer therapy.
Dr. Martijn S. Bijker
Leiden University Medical Center
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In this thesis we have explored the mechanisms of minimal and extended CTL peptide-based vaccines to induce an optimal immune response, without the risk for tolerance induction.
Minimal CTL peptide vaccinations are widely used to induce a CD8+ T cell response in cancer patients, however, without the expected success. Extended peptides have recently been shown to be far more efficient. This thesis will outline why these extended peptide vaccines are more potent than minimal peptide vaccines.
