Keynote lecture “Resolution of Inflammation”

Carla V Rothlin, PhD

Keynote lecture “Resolution of Inflammation”rothlin.jpg

Carla V Rothlin, PhD
Associate Professor of Immunobiology and Pharmacology
Yale University School of Medicine
Department of Immunobiology

Dr. Rothlin’s laboratory focuses on mechanisms that underlie the regulation of inflammation and the homeostatic control of immune function.  Having discovered a signaling pathway downstream of the TAM (Tyro3, Axl, Mer) receptor tyrosine kinases that limits the amplitude and phase of the inflammatory response, they currently focus on identifying the in vivo source of TAM ligands, unraveling the molecular determinants that account for the specificity of TAM-mediated inhibition, decoding the transcriptome activated during TAM-mediated inhibition of inflammation, testing the role of TAM-mediated immune suppression in vivo, and employing established animal models of chronic inflammatory and infectious diseases.

Selected publications:

  • Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.
    Bosurgi L, Cao YG, Cabeza-Cabrerizo M, Tucci A, Hughes LD, Kong Y, Weinstein JS, Licona-Limon P, Schmid ET, Pelorosso F, Gagliani N, Craft JE, Flavell RA, Ghosh S, Rothlin CV.
    Science. 2017 Jun 9;356(6342):1072-1076
  • The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity.
    Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard EG, Torgerson DG, Ghosh S, Rothlin CV.
    Science. 2016 Apr 1;352(6281):99-103.
  • TAM receptor signaling in immune homeostasis.
    Rothlin CV, Carrera-Silva EA, Bosurgi L, Ghosh S.
    Annu Rev Immunol. 2015;33:355-91.

Carla Rothlin was born and raised in Buenos Aires, Argentina. She studied Biochemistry and Pharmacy at the University of Buenos Aires, where she also performed her graduate studies under the direction of Belen Elgoyhen on nicotinic receptors expressed in the inner ear. Following her Ph.D., Dr. Rothlin moved to San Diego, California and joined Greg Lemke's lab at the Salk Institute for Biological Studies. While she originally intended to continue her training in Neuroscience, Dr. Rothlin started to work on a family of receptor tyrosine kinases - the TAMs - which introduced her to the immunobiology world. In 2009, Dr. Rothlin joined the Department of Immunobiology at Yale University as an Assistant Professor. Dr. Rothlin is currently an Associate Professor and HHMI Faculty Scholar.

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