Keynote lecture: "Concepts of T cell activation from a spatio-temporal perspective"

Wolfgang Kastenmüller, MD

Keynote lecture: "Concepts of T cell activation from a spatio-temporal perspective"

Wolfgang Kastenmüller, MDwolfgangkastenmuller.jpg
Director Institute of Systemsimmunology I - University of Würzburg
Group leader Institute of Experimental Immunology - University of Bonn

Wolfgang Kastenmuller received his M.D. from the TU Munich, where he was also trained as an infectious disease specialist. He then carried out his post-doctoral training with Ronald N. Germain at the NIH, USA. In 2013 he returned to Germany to start his independent group at the University Bonn and has recently been recruited as Professor for Systems Immunology to the University of Würzburg. His lab focuses on cell-cell communication and interactions in the context of infectious diseases with a specific interest in the interface between innate and adaptive immunity. Using  intravital microscopy his lab has identified the spatiotemporal dynamics of lymphocyte activation in the context of viral infections. In particular, his team has uncovered how CD4 T cell help for cytotoxic lymphocytes is orchestrated.

Selected publications:

  • CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.
    Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W.
    Immunity. 2017 Feb 21;46(2):205-219. doi: 10.1016/j.immuni.2017.01.003. Epub 2017 Feb 9.
  • Parallels and differences between innate and adaptive lymphocytes.
    Bedoui S, Gebhardt T, Gasteiger G, Kastenmüller W.
    Nat Immunol. 2016 May;17(5):490-4. doi: 10.1038/ni.3432.
  • Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions.
    Eickhoff S, Brewitz A, Gerner MY, Klauschen F, Komander K, Hemmi H, Garbi N, Kaisho T, Germain RN, Kastenmüller W.
    Cell. 2015 Sep 10;162(6):1322-37. doi: 10.1016/j.cell.2015.08.004. Epub 2015 Aug 18.
  • A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread.
    Kastenmüller W, Torabi-Parizi P, Subramanian N, Lämmermann T, Germain RN.
    Cell. 2012 Sep 14;150(6):1235-48. doi: 10.1016/j.cell.2012.07.021.
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