PhD student

Within this translational research setting, we will investigate the molecular processes that regulate T cell and monocyte function. A better understanding of these fundamental processes can pave the way for novel therapeutic strategies to treat autoimmune diseases such as Juvenile Idiopathic Arthritis. More specifically, we will investigate the role of RNA-methylation in immune activation and autoimmune diseases. RNA-methylation is a relatively underexplored post-transcriptional process that (amongst others) regulates RNA/protein expression. We will assess the signaling pathways that regulate RNA-methylation in immune cells and evaluate the impact of RNA-methylation on immune activation. The PhD student will utilize various techniques including: RNA-seq, MeRIP-seq, CRISPR/Cas9, cloning, cell culture, flow cytometry, transductions, transfections, Western blot, Q-PCR, and BioID.

The mission of the van Loosdregt-Vastert research group is to increase our understanding of the molecular mechanisms underlying autoimmune diseases and translating these findings into novel therapeutics. Our group consists of both fundamental and clinical scientists in order to efficiently translate findings from the lab to the clinic.

requirements

We expect the PhD student to be independent and flexible in setting-up, executing, and interpreting experiments. And have a strong drive for a career in science. Communicate data at scientific meetings and by publications in scientific journals. And work well in a team.

The maximum salary for this position (100%) is € 2.919,00 gross per month based on full-time employment (work week 36 hours). This job is based on a temporary position for 4 years.

In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses, career opportunities and personal budget. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

salary max € 2.919,00 gross per month
job type full time (36 hours a week)
start
end
organisation UMC Utrecht
department The Laboratory of Translational Immunology
location Wilhelmina Kinderziekenhuis, Utrecht
contact

More information

If you have any questions about this vacancy, please contact Mr.Dr. J van Loosdregt, PI, phone 088-7754091. Email j.vanloosdregt@umcutrecht.nl .

organization profile

The Laboratory of Translational Immunology provides an international, dynamic, and stimulating work environment. Numerous state-of-the-art techniques are available and we have various (international) collaborations. Our group is embedded within the Child Health and Immunity and Infection UMCU focus areas.
(https://www.umcutrecht.nl/en/Research/Research-programs/Infection-Immunity/Group-van-Loosdregt-Vastert )

(http://www.umcutrecht.nl/en/Research/Research-programs/Child-Health )

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