PhD vacancy: Targeting immunometabolism in tumour-associated macrophages
Your work environment Within the department of Molecular Cell Biology and Immunology at VU University Medical Center (VUmc, Amsterdam), our group studies the metabolic characteristics and requirements of macrophages. This project incorporates fundamental research questions as well as translational applications in in vivo models, human in vitro models and analysis of glioblastoma patient material with the ultimate goal to translate our findings to the clinic. You will work in a team with young and enthusiastic researchers, who have expertise in immunology, biochemistry, cell biology, cancer and cardiovascular disease. This CCA (Cancer Center Amsterdam) project will be performed in close collaboration with Dr. J. J. Garcia Vallejo and Prof. Y. van Kooyk.
Your challenge
The successful candidate will study the immunometabolic alterations in human tumour-associated macrophages (TAMs) and will address the importance of this process with both in vitro tools and in vivo mouse cancer models.
As a junior researcher, your main tasks and responsibilities are:
• Integrating transcriptomics and metabolomics data to define immunometabolic circuits in macrophages.
• Identifying new metabolic regulators that control macrophage function
• Validating new targets in mouse models of cancer
• You will use state-of-the-art high-dimensional cytometry techniques, RNA-sequencing, metabolomics, and will apply bioinformatics to analyze the data.
requirements | Your profile |
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salary | 2244 to 2874 euro gross when employed full-time (depending on qualifications and | |
job type | PhD | |
start | 01-06-2018 | |
end | ||
organisation | VU University Medical Center | |
department | Moleculer Cell Biology and Immunology | |
location | Amsterdam | |
contact | You can apply until 24 April 2018 via: |
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organization profile | Research within the department of Molecular Cell Biology and Immunology is performed in the vibrant environment of the O|2 Lab Building (www.o2labbuilding.com) and at an international high competitive level. The department consists of several research groups that study cellular and molecular interactions in health and disease. |