Postdoc B-T cell immunity (I&V-IIV-051)

Understanding a normal B cell response is of great importance. Malfunctioning of this response can lead to uncontrolled B cell proliferation and differentiation, and formation of autoreactive or malignant B cell memory and (auto)antibodies. You will investigate the initiation of human B cell immunity after infection and vaccination. You will dissect which molecular and cellular key factors regulate the activation and differentiation of antigen-specific B cells. The focus will be to unravel B-T cell interactions. Your research will use unique clinical infection- or vaccination-cohorts, or population wide cohorts. You will investigate the effects of age and pre-existing antibodies on B cell responses. You will use cell isolation, in vitro cell culture and differentiation systems, multicolour flow cytometry and antibody assays, as well as biomarker analyses at a protein-, RNA- and (epi)genetic-level. In addition, you will provide input on new projects focusing on immunological topics that are relevant for the public health and the national immunization program.

This post-doc position is part of the Target-to-B! consortium, which is a national consortium funded by the Top Sector Life Sciences & Health and the Dutch Collaborative Health Funds. The involvement and role of B cells and antibodies in health as well as the development of autoimmunity and cancer will be studied in a
disease-overarching approach by several leading groups in the Netherlands. Your research will be in close collaboration with other research groups within the Target-to-B! consortium, and teamwork and strong
communication skill are desirable.


We are looking for:
• a PhD in immunology
• strong affinity with human cellular immunology
• experience with primary cell cultures and multi-colour flow cytometry
• experience with multiplex assays and (functional) antibody assays is desirable
• affinity with RNAseq, systems immunology and big data bioinformatics is desirable
• excellent skills in English (speech and writing)
• teamplayer with excellent communication skills
• innovative in scientific questions, presentation and publication
• respectful colleague.

salary €2631,- to €4229,- gross per month
job type Post-Doc
start 01-04-2019
end 01-04-2021
organisation National Institute for Public Health and the Environment (RIVM)
department Centre for Immunology of Infectious Diseases and Vaccines
location Bilthoven

Responding deadline for this vacancy is 4th February 2019

You can apply via this link:

For more information about the vacancy please contact:
Cécile van Els, Sr. scientific researcher
+31 30-274 3665

More information regarding the procedure (vacaturebeheer):
Linda de Greef-Norden, 030-274 3682
Asmae Uali, 030-274 2054

organization profile

The Dutch National Institute for Public Health and the Environment (RIVM) protects and promotes public health and consumer safety, and we help to protect the quality of the environment. We’ve done so for more
than a hundred years and RIVM has become a knowledge institute that is at the heart of society. RIVM carries out independent research and provides the government with trusted policy advice regarding health and the environment. We deal with issues concerning infectious diseases, vaccinations, population studies, lifestyle, nutrition, drugs, the environment, sustainability and safety. We do this through research, advice, direction or implementation. RIVM annually produces and publishes numerous reports. RIVM has a total of approximately 1.800 staff.

The center for Immunology of Infectious Diseases and Vaccines (IIV) at RIVM is thé knowledge center of the government in the field of immunology of infectious diseases and vaccines. The core mission of this center is to provide information and advice about effectiveness of vaccines, vaccination strategies and immune responses against infectious diseases to parties within the government and to the general public. In support of this task, research performed at IIV is focused on optimization of the effectiveness and safety of current
and future vaccination programs, immunosurveillance, age-related efficacy of the immune responses and correlates of protection. In this work the center collaborates intensively with other RIVM knowledge centers

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