Post-doc Scientist Molecular biology / Biochemistry / Immuno-Oncology

Acute myeloid leukemia (AML) is a devastating disease with a high mortality. Patients often need the immunotherapeutic effect of an allogeneic hematopoietic stem cell transplantation (HCT) to be cured. We have demonstrated that AML patients who are cured after allogeneic HCT develop AML-specific antibody responses. Some of these antibodies with broad reactivity against AML cells of patients have the potential to be further developed into therapeutic antibodies.

This research is performed at the Department of Hematology, Experimental Immunology and in close collaboration with the biotechnology company AIMM Therapeutics. We have an opportunity for a highly motivated and experienced scientist to strengthen our team. The candidate will be involved in the biochemical and functional characterization of novel therapeutic antibodies for treatment of AML. The candidate has a proven track-record in biochemistry and immunology and in the application of novel biochemical and molecular biology technologies for solving complex biological problems. He/she has a broad understanding of and experience with next generation sequencing, immune repertoire profiling and their applications.


We offer an initial contract for 12 months that can be extended (after evaluation) for another 24 months.

requirements

A post-doctoral researcher with at least 4 years’ experience in molecular biology, biochemistry, in structural biology of macromolecular protein complexes, gene structures, cell biology or immunology. The candidate should have proven ability to independently perform scientific research, and develop and troubleshoot new experimental techniques and protocols.

salary market conform and depending on experience
job type full time (36 hrs/week)
start 01-09-2020
end 01-09-2021
organisation Amterdam UMC-location AMC
department Hematology, Experimental Immunology
location Amsterdam
contact

Mette Hazenberg (m.d.hazenberg@amsterdamumc.nl)  
Hergen Spits (hergen.spits@amsterdamumc.nl),  
Bianca Blom (b.blom@amsterdamumc.nl).

organization profile

The Amsterdam UMC is an academic hospital in which patient care, student education and scientific research are the main pillers.

We are part of the Amsterdam institute for Infection and Immunity (AII; https://www.amsterdamresearch.org/web/amsterdam-infection-and-immunity/home.htm) that has a focus on different research programs, including Cancer immunology, Infectious diseases and Inflammatory diseases. The multidisciplinary nature of our research aims at development of new diagnostics and clinical applications by performing innovative fundamental, translational and clinical research.

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